'' '' '' '' '' ''

Abstract                 Volume:4  Issue-12  Year-2017          Original Research Articles

IJCRBP is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCRBP Articles.

Online ISSN : 2349-8080
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorinchiefijcrbp@gmail.com

Halogenated (F, Cl, Br, I) Anabolic Steroids and their Biological Activities
Anna Kilimnik1, Tatyana A. Gloriozova2 and Valery M. Dembitsky3*
1National Institute of Water and Atmospheric Research, Private Bag 14-901, Wellington 6241, New Zealand
2 Institute of Biomedical Chemistry, Moscow, Russia 119 121
3 Biochemistry Laboratory, National Scientific Center of Marine Biology, 17 Palchevsky Str., Vladivostok, Russia 690 041  
*Corresponding author
Abstract:

The present review describes the biological activities of synthetic anabolic halogenated (F, Cl, Br and I) steroids. About sixty biologically active halogenated steroids have shown confirmed anti-inflammatory, estrogenic, anabolic, gynecological disorders, anti-arthritic, antineoplastic, and other activities. The structures and reported and predicted activities of halogenated steroids are available. With the computer programme PASS and based on structure–activity relationships (SAR), some additional activities are also predicted, which point towards new possible applications of these lipids. This review emphasizes the role of halogenated steroids as an important source and potential leads for drug discovery and they are of great interest to chemists, physicians, biologists, pharmacologists and the pharmaceutical industry.

Keywords: Anabolic activities,Halogenated,Lipids,PASS,SAR,Steroids
Download this article as Download

How to cite this article:

Kilimnik, A., Gloriozova, T. A., Dembitsky, V. M., 2017. Halogenated (F, Cl, Br, I) anabolic steroids and their biological activities.Int.J.Curr.Res.Biosci.Plantbiol. 4(12): 68-93. doi: https://doi.org/10.20546/ijcrbp.2017.412.006
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.