|Online ISSN : 2349-8080
Issues : 12 per year
Publisher : Excellent Publishers
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2 Institute of Biomedical Chemistry, Moscow, Russia 119121
The present review describes the biological activities of natural plant chlorinated steroids. About forty biologically active chlorinated steroids have shown confirmed cytostatic, antineoplastic, anti-eczematic, antidiabetic, antibacterial, and other activities. The structures and reported and predicted activities of chlorinated steroids are available. With the computer programme PASS and based on structure–activity relationships (SAR), some additional activities are also predicted, which point towards new possible applications of these lipids. This review emphasizes the role of chlorinated steroids as an important source and potential leads for drug discovery and they are of great interest to chemists, physicians, biologists, pharmacologists and the pharmaceutical industry.